Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC010
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-09-06 09:23
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment old patient Madopar HBS 2 x1 Madopar 250mg 4x1

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 19 individuals with a value less than 0.57 were subsequently diagnosed with PD. That is, 45.24% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.57 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 2, 'TN': 2, 'TP': 40, 'FP': 28}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 34, 'TN': 27, 'TP': 8, 'FP': 3}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 33, 'TN': 28, 'TP': 9, 'FP': 2}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 18, 'TN': 10, 'TP': 24, 'FP': 20}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 18.036
timePerCircleCoV 0.116487
timePerCircleSlope -0.00885771
meanError 1.21167
tremorFreq 6.25
tremorRelPower 30.6775
tremorGyroAmpMean 0.0192426
tremorGyroAmpSlope -4.87191e-05
tremorGyroAmpCoV 0.457068
tremorCoordAmpMean 0.0553865
tremorCoordAmpSlope 0.00965081
tremorCoordAmpCoV 2.22831
tremorAccAmpMean 0.0732502
tremorAccAmpSlope -9.04096e-05
tremorAccAmpCoV 0.0458898
tremorPcRelVar 0.708608
tremorPcX -0.647009
tremorPcY -0.762482

Circle Segment 1

Duration 20.2 s, Accuracy Estimate 1.146 (lower is better)

Circle Segment 2

Duration 18.08 s, Accuracy Estimate 1.279 (lower is better)

Circle Segment 3

Duration 18.32 s, Accuracy Estimate 1.257 (lower is better)

Circle Segment 4

Duration 15.0 s, Accuracy Estimate 1.152 (lower is better)

Circle Segment 5

Duration 18.8 s, Accuracy Estimate 1.112 (lower is better)

Circle Segment 6

Duration 17.52 s, Accuracy Estimate 1.028 (lower is better)

Circle Segment 7

Duration 22.12 s, Accuracy Estimate 0.795 (lower is better)

Circle Segment 8

Duration 15.72 s, Accuracy Estimate 1.56 (lower is better)

Circle Segment 9

Duration 18.24 s, Accuracy Estimate 1.137 (lower is better)

Circle Segment 10

Duration 16.36 s, Accuracy Estimate 1.651 (lower is better)

Spiral

numSpirals 6
timePerSpiralMean 48.8533
timePerSpiralCoV 0.0921882
timePerSpiralSlope -0.00692452
meanError 1.65943
tremorFreq 6.15234
tremorRelPower 31.8039
tremorGyroAmpMean 0.0163765
tremorGyroAmpSlope 0.000389483
tremorGyroAmpCoV 0.338859
tremorCoordAmpMean 0.035863
tremorCoordAmpSlope 0.000535238
tremorCoordAmpCoV 1.94425
tremorAccAmpMean 0.0685211
tremorAccAmpSlope 0.000120534
tremorAccAmpCoV 0.049824
tremorPcRelVar 0.58496
tremorPcX -0.967521
tremorPcY -0.252789

Spiral Segment 1

Duration 55.68 s, Accuracy Estimate 1.571 (lower is better)

Spiral Segment 2

Duration 44.92 s, Accuracy Estimate 1.527 (lower is better)

Spiral Segment 3

Duration 46.76 s, Accuracy Estimate 1.745 (lower is better)

Spiral Segment 4

Duration 47.72 s, Accuracy Estimate 1.732 (lower is better)

Spiral Segment 5

Duration 44.92 s, Accuracy Estimate 1.655 (lower is better)

Spiral Segment 6

Duration 53.12 s, Accuracy Estimate 1.728 (lower is better)

Elel

eDurationMean 0.828571
eDurationStd 0.415525
eDurationStdnorm 0.501496
eDurationMedian 0.7325
eDurationQuartdelta 0.165
eDurationQuartdeltanorm 0.225256
eDurationKurt 14.0472
eDurationTrenddiff -0.145
eDurationTrendratio 0.81761
eWidthMean 7.21221
eWidthStd 2.74253
eWidthStdnorm 0.380262
eWidthMedian 6.201
eWidthQuartdelta 3.627
eWidthQuartdeltanorm 0.584906
eWidthKurt 3.46581
eWidthTrenddiff 1.053
eWidthTrendratio 1.19149
eHeightMean 12.2739
eHeightStd 2.46545
eHeightStdnorm 0.20087
eHeightMedian 12.3435
eHeightQuartdelta 2.691
eHeightQuartdeltanorm 0.218009
eHeightKurt 2.43162
eHeightTrenddiff 1.989
eHeightTrendratio 1.17526
eAspectMean 0.579905
eAspectStd 0.14479
eAspectStdnorm 0.249679
eAspectMedian 0.546452
eAspectQuartdelta 0.2
eAspectQuartdeltanorm 0.365998
eAspectKurt 2.56015
eAspectTrenddiff -0.000119875
eAspectTrendratio 0.999781
eSlantMean 0.125007
eSlantStd 0.235205
eSlantStdnorm 1.88154
eSlantMedian 0.0630379
eSlantQuartdelta 0.345452
eSlantQuartdeltanorm 5.48006
eSlantKurt 2.23022
eSlantTrenddiff -0.0259078
eRtopMean 0.726885
eRtopStd 0.136213
eRtopStdnorm 0.187392
eRtopMedian 0.740018
eRtopQuartdelta 0.148417
eRtopQuartdeltanorm 0.200559
eRtopKurt 3.39277
eRtopTrenddiff 0.0253723
eRbotMean 0.568704
eRbotStd 0.27159
eRbotStdnorm 0.477559
eRbotMedian 0.570835
eRbotQuartdelta 0.380847
eRbotQuartdeltanorm 0.667174
eRbotKurt 2.46196
eRbotTrenddiff 0.243774
eRrightMean 0.85464
eRrightStd 0.097415
eRrightStdnorm 0.113984
eRrightMedian 0.876096
eRrightQuartdelta 0.0970714
eRrightQuartdeltanorm 0.1108
eRrightKurt 6.74175
eRrightTrenddiff 0.00219298
eRleftMean 0.385803
eRleftStd 0.139391
eRleftStdnorm 0.361301
eRleftMedian 0.381525
eRleftQuartdelta 0.211211
eRleftQuartdeltanorm 0.553597
eRleftKurt 2.74986
eRleftTrenddiff 0.0155756
lDurationMean 1.10282
lDurationStd 0.31939
lDurationStdnorm 0.289612
lDurationMedian 1.015
lDurationQuartdelta 0.3125
lDurationQuartdeltanorm 0.307882
lDurationKurt 5.80081
lDurationTrenddiff -0.225
lDurationTrendratio 0.805195
lWidthMean 16.179
lWidthStd 4.32242
lWidthStdnorm 0.267162
lWidthMedian 14.625
lWidthQuartdelta 6.201
lWidthQuartdeltanorm 0.424
lWidthKurt 3.21352
lWidthTrenddiff 2.457
lWidthTrendratio 1.17213
lHeightMean 33.873
lHeightStd 5.00205
lHeightStdnorm 0.147671
lHeightMedian 33.579
lHeightQuartdelta 6.69825
lHeightQuartdeltanorm 0.199477
lHeightKurt 2.81202
lHeightTrenddiff 6.435
lHeightTrendratio 1.21912
lAspectMean 0.4748
lAspectStd 0.0868797
lAspectStdnorm 0.182982
lAspectMedian 0.461538
lAspectQuartdelta 0.107279
lAspectQuartdeltanorm 0.232438
lAspectKurt 3.13231
lAspectTrenddiff -0.00457548
lAspectTrendratio 0.99015
lSlantMean 0.278547
lSlantStd 0.113793
lSlantStdnorm 0.408522
lSlantMedian 0.277778
lSlantQuartdelta 0.160781
lSlantQuartdeltanorm 0.578812
lSlantKurt 2.34711
lSlantTrenddiff -0.0115995
lRtopMean 0.868927
lRtopStd 0.0579396
lRtopStdnorm 0.0666795
lRtopMedian 0.872549
lRtopQuartdelta 0.051743
lRtopQuartdeltanorm 0.059301
lRtopKurt 4.45727
lRtopTrenddiff -0.00765259
lRbotMean 0.299206
lRbotStd 0.127206
lRbotStdnorm 0.425146
lRbotMedian 0.280702
lRbotQuartdelta 0.140625
lRbotQuartdeltanorm 0.500975
lRbotKurt 2.76808
lRbotTrenddiff 0.0279251
lRrightMean 0.929159
lRrightStd 0.0355402
lRrightStdnorm 0.0382499
lRrightMedian 0.931373
lRrightQuartdelta 0.0392799
lRrightQuartdeltanorm 0.0421742
lRrightKurt 5.36713
lRrightTrenddiff -0.014141
lRleftMean 0.20463
lRleftStd 0.0772522
lRleftStdnorm 0.377521
lRleftMedian 0.204819
lRleftQuartdelta 0.111795
lRleftQuartdeltanorm 0.545823
lRleftKurt 3.07373
lRleftTrenddiff -0.0311426

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.828658
sumTouchScores 8.28658
meanMovementTime 1.78778
numTouches 10
undershootPercentage 0
overshootPercentage 40

FITTS Long Modified

meanTouchScore 0.949328
sumTouchScores 12.3413
meanMovementTime 1.26292
numTouches 13
undershootPercentage 0
overshootPercentage 0

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 39.776
timePerZigzagCoV 0.0454908
timePerZigzagSlope -0.0124698
meanError 1.87105
tremorFreq 6.05469
tremorRelPower 27.4344
tremorGyroAmpMean 0.018834
tremorGyroAmpSlope -0.00131974
tremorGyroAmpCoV 0.39236
tremorCoordAmpMean 0.0446039
tremorCoordAmpSlope -0.000317622
tremorCoordAmpCoV 0.431794
tremorAccAmpMean 0.0388737
tremorAccAmpSlope -0.000228011
tremorAccAmpCoV 0.225376
tremorPcRelVar 0.735213
tremorPcX 0.356292
tremorPcY 0.934375

ZigZag Segment 1

Duration 42.0 s, Accuracy Estimate 2.174 (lower is better)

ZigZag Segment 2

Duration 40.44 s, Accuracy Estimate 1.805 (lower is better)

ZigZag Segment 3

Duration 37.52 s, Accuracy Estimate 1.708 (lower is better)

ZigZag Segment 4

Duration 38.36 s, Accuracy Estimate 1.828 (lower is better)

ZigZag Segment 5

Duration 40.56 s, Accuracy Estimate 1.841 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 28.696
timePerZigzagCoV 0.0714418
timePerZigzagSlope -0.0434904
zigzagHeightMean 62.9031
zigzagHeightCoV 0.03782
zigzagHeightSlope 0.020395
meanError 0.0434955
tremorFreq 6.44531
tremorRelPower 30.79
tremorGyroAmpMean 0.0208066
tremorGyroAmpSlope 0.00172152
tremorGyroAmpCoV 0.450666
tremorCoordAmpMean 0.0857746
tremorCoordAmpSlope 0.00228547
tremorCoordAmpCoV 1.09899
tremorAccAmpMean 0.0339718
tremorAccAmpSlope 0.000675558
tremorAccAmpCoV 0.330456
tremorPcRelVar 0.876826
tremorPcX -0.0910877
tremorPcY 0.995843

ZigZag Offset Segment 1

Duration 30.56 s, Accuracy Estimate 0.062 (lower is better)

ZigZag Offset Segment 2

Duration 30.64 s, Accuracy Estimate 0.025 (lower is better)

ZigZag Offset Segment 3

Duration 29.12 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 4

Duration 27.04 s, Accuracy Estimate 0.025 (lower is better)

ZigZag Offset Segment 5

Duration 26.12 s, Accuracy Estimate 0.075 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘PD’, ‘HiSpec_score’: 0.32}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.57}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.07444714957630882}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9203181861682241}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.6452976482613707}